Synthesis, Structure, Stability, and Inhibition of Tubulin Polymerization by Ru^II-p-Cymene Complexes of Trimethoxyaniline-Based Schiff Bases.

ABSTRACT: Four trimethoxy- and dimethoxyphenylamine-based Schiff base (L1-L4)-bearing Ru^II-p-cymene complexes (1-4) of the chemical formula [Ru^II(η⁶-p-cymene)(L)(Cl)] were synthesized, isolated in pure form, and structurally characterized using single-crystal X-ray diffraction and other analytical techniques. The complexes showed excellent in vitro antiproliferative activity against various forms of cancer that are difficult to cure, viz., triple negative human metastatic breast carcinoma MDA-MB-231, human pancreatic carcinoma MIA PaCa-2, and hepatocellular carcinoma Hep G2. The ¹H nuclear magnetic resonance data in the presence of 10% dimethylformamide-d₇ or dimethyl sulfoxide-d₆ in ph

SUBMITTER: Acharya S 

PROVIDER: S-EPMC7165017 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature