Anesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults.

ABSTRACT:

Background

We evaluated the hypothesis that the rate of postoperative decline in global cognition is greater in older adults exposed to general anesthesia with nitrous oxide (N2O) compared to general anesthesia without N2O.

Methods

Longitudinal measures of cognitive function were analyzed in nondemented adults, 70-91 years of age, enrolled in the Mayo Clinic Study of Aging. Linear mixed-effects models with time-varying covariates assessed the relationship between exposure to surgery with general anesthesia (surgery/GA) with or without N2O and the rate of long-term cognitive changes. Global cognition and domain-specific cognitive outcomes were defined using z scores, which measure how far an observation is, in standard deviations, from the unimpaired population mean.

Resul

SUBMITTER: Sprung J 

PROVIDER: S-EPMC7165021 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature