B₀-field dependence of MRI T₁ relaxation in human brain.

ABSTRACT: Tissue longitudinal relaxation characterized by recovery time T₁ or rate R₁ is a fundamental MRI contrast mechanism that is increasingly being used to study the brain's myelination patterns in both health and disease. Nevertheless, the quantitative relationship between T₁ and myelination, and its dependence on B₀ field strength, is still not well known. It has been theorized that in much of brain tissue, T₁ field-dependence is driven by that of macromolecular protons (MP) through a mechanism called magnetization transfer (MT). Despite the explanatory power of this theory and substantial support from in-vitro experiments at low fields (<3 ​T), in-vivo evidence across clinically relevant field strengths is lacking. In this study, T₁

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7165058 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature