Sex Differences in Adverse Drug Reactions of Metformin: A Longitudinal Survey Study.

ABSTRACT:

Introduction

In general, women more often experience metformin-associated adverse drug reactions (ADRs) than men.

Objectives

We aimed to assess whether sex differences in reported ADRs for metformin are observed at different times after initiation, and to explore their concurrence with sex differences in the dose of metformin over time. This may guide future studies in assessing the involved mechanisms of sex differences in metformin-associated ADRs and may guide sex-specific management of ADRs in clinical practice.

Methods

This study has a longitudinal design using data about patients initiating metformin collected by the Dutch National Pharmacovigilance Center Lareb through their Intensive Monitoring program. Patients were asked to complete a web-based questionnaire

SUBMITTER: de Vries ST 

PROVIDER: S-EPMC7165141 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature