Age related retinal Ganglion cell susceptibility in context of autophagy deficiency.

ABSTRACT: Glaucoma is a common age-related disease leading to progressive retinal ganglion cell (RGC) death, visual field defects and vision loss and is the second leading cause of blindness in the elderly worldwide. Mitochondrial dysfunction and impaired autophagy have been linked to glaucoma and induction of autophagy shows neuroprotective effects in glaucoma animal models. We have shown that autophagy decreases with aging in the retina and that autophagy can be neuroprotective for RGCs, but it is currently unknown how aging and autophagy deficiency impact RGCs susceptibility and survival. Using the optic nerve crush model in young and olWelcome@1234d Ambra1 ^+/gt (autophagy/beclin-1 regulator 1^+/gt) mice we analysed the contribution of autophagy deficiency on retinal g

SUBMITTER: Bell K 

PROVIDER: S-EPMC7165178 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature