Relationship between Surgery under General Anesthesia and the Development of Dementia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

To investigate the association between exposure to general anesthesia and the development of Alzheimer's disease (AD) and dementia by reviewing and integrating the evidence from epidemiological studies published to date.

Methods

We searched MEDLINE, EMBASE, and Google Scholar to identify all relevant articles up to April 2018 reporting the risk of AD/dementia following exposure to general anesthesia and finally updated in February 2020. We included patients older than 60 or 65 years who had not been diagnosed with dementia or AD before the study period. The overall pooled effect size (ES) was evaluated with a random-effect model. Subgroup analyses were conducted and possibility of publication bias was assessed.

Results

A total of 23 studies with 412253 patie

SUBMITTER: Lee JJ 

PROVIDER: S-EPMC7165327 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature