Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism.

ABSTRACT:

Introduction

Low gut microbiome richness is associated with dyslipidemia and insulin resistance, and ceramides and other sphingolipids are implicated in the development of diabetes.

Objectives

Determine whether circulating sphingolipids, particularly ceramides, are associated with alterations in the gut microbiome among obese patients with increased diabetes risk.

Methods

This was a cross-sectional and longitudinal retrospective analysis of a dietary/weight loss intervention. Fasted serum was collected from 49 participants (41 women) and analyzed by HPLC-MS/MS to quantify 45 sphingolipids. Shotgun metagenomic sequencing of stool was performed to profile the gut microbiome.

Results

Confirming the link to deteriorated glucose homeostasis, serum ceramides were pos

SUBMITTER: Kayser BD 

PROVIDER: S-EPMC7165363 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature