Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression.

ABSTRACT: BACKGROUND:Emotional health disturbances are common after aneurysmal subarachnoid hemorrhage (aSAH) and their causes are largely unexplored. Corticotropin-releasing hormone receptor 1 (CRHR1) is a key factor in stress reactivity and development of mental health disturbances after adverse life-events. METHODS:We explore the effect of CRHR1 genotype on mental health after aSAH in a retrospective cohort study. One hundred twenty-five patients have been assessed using EST-Q mental health questionnaire. Genotyping of CRHR1 single nucleotide polymorphisms (SNP-s) was performed (Rs7209436, Rs110402, Rs242924). RESULTS:Fatigue was present in almost half of aSAH patients, depression and anxiety in one-third. There was a high prevalence of insomnia and panic complaints. Rs110402 minor allele decreas

SUBMITTER: Vetkas A 

PROVIDER: S-EPMC7165373 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature