Temporal transcriptome change of Oncomelania hupensis revealed by Schistosoma japonicum invasion.

ABSTRACT:

Background

The freshwater snail Oncomelania hupensis is the obligate intermediate host for Schistosoma japonicum in China. Transcriptomic examination of snail-schistosome interactions can provide valuable information of host response at physiological and immune levels.

Methods

To investigate S. japonicum-induced changes in O. hupensis gene expression, we utilized high-throughput sequencing to identify transcripts that were differentially expressed between infected snails and their uninfected controls at two key time-point, Day 7 and Day 30 after challenge. Time-series transcriptomic profiles were analyzed using R package DESeq 2, followed by GO, KEGG and (weighted gene correlation network analysis) WGCNA analysis to elucidate and identify importan

SUBMITTER: Feng X 

PROVIDER: S-EPMC7165382 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature