Suppressed T cell-mediated immunity in patients with COVID-19: A clinical retrospective study in Wuhan, China.

ABSTRACT:

Importance

An ongoing outbreak of COVID-19 has exhibited significant threats around the world. We found a significant decrease of T lymphocyte subsets and an increase of inflammatory cytokines of hospitalized patients with COVID-19 in clinical practice.

Methods

We conducted a retrospective, single-center observational study of in-hospital adult patients with confirmed COVID-19 in Hubei Provincial Hospital of traditional Chinese and Western medicine (Wuhan, China) by Mar 1, 2020. Demographic, clinical, laboratory information, especially T lymphocyte subsets and inflammatory cytokines were reported. For patients who died or discharge from hospital, the associations of T lymphocyte subsets on admission were evaluated by univariate logistic regression with odds ratios (ORs) and

SUBMITTER: Xu B 

PROVIDER: S-EPMC7166040 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature