CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells.

ABSTRACT: Homotypic aggregation (HA) of cells plays key roles in physiological and pathological processes, such as embryogenesis, immune responses, angiogenesis, tumor cell invasion, and metastasis. Aminopeptidase N (CD13) has been implicated in most of these phenomena, although its participation has been attributed to its enzymatic activity, while its role as an adhesion molecule has been almost unexplored. Here, we show that certain anti-CD13 monoclonal antibodies induce HA of monocytic U-937 cells, independently of their effect on enzymatic activity. The phenomenon is related to binding to a specific site on the CD13 molecule and is independent of integrins. It is abrogated by low temperature, by the glycolysis inhibitor 2-deoxyglucose, and by inhibitors of tyrosine and mitogen-activated protein

SUBMITTER: Mina-Osorio P 

PROVIDER: S-EPMC7166514 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature