Dataset Information

Circulation of human metapneumovirus among children with influenza-like illness in Wuhan, China.

ABSTRACT: Human metapneumovirus (HMPV) is a worldwide distributed pathogen of the respiratory tract. The objectives of this study were to identify HMPV infections among children with influenza-like illness (ILI) in Wuhan and to assess circulation patterns and molecular diversity of HMPV in this area. From July 2008 to December 2013, a total of 3,883 throat swab samples were collected from ILI outpatients under 16 years old. HMPV RNA was detected in 171 samples (4.40%). All the four subtypes of HMPV were identified, among which A2 was the most common subtype (61/145, 42.1%), followed by B1, B2, and A1. During the study period, HMPV circulation presented a biennial alternation between high and low incidence in Wuhan and the seasonal peak also shift between winter and spring in two continuous seasons. Subtype A2, B1, and B2 co-circulated during the study period, with genotype A prevailing in epidemic season 2008-2009 and 2012-2013, and genotype B prevailing during other periods. This large-scale analysis of HMPV prevalence in ILI outpatient children improves the understanding of local HMPV circulation patterns and provides molecular epidemic evidence for comparative analysis of HMPV infection.

SUBMITTER: Kong W

PROVIDER: S-EPMC7166970 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Circulation of human metapneumovirus among children with influenza-like illness in Wuhan, China.

Kong Wenhua W Wang Ying Y Zhu Honghao H Lin Xinming X Yu Bin B Hu Quan Q Yang Xiaobing X Guo Deyin D Peng Jinsong J Zhou Dunjin D

Journal of medical virology 20160107 5

Human metapneumovirus (HMPV) is a worldwide distributed pathogen of the respiratory tract. The objectives of this study were to identify HMPV infections among children with influenza-like illness (ILI) in Wuhan and to assess circulation patterns and molecular diversity of HMPV in this area. From July 2008 to December 2013, a total of 3,883 throat swab samples were collected from ILI outpatients under 16 years old. HMPV RNA was detected in 171 samples (4.40%). All the four subtypes of HMPV were i ...[more]

PMID: 26488078

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Project description:BackgroundInfluenza is a common viral respiratory infection that causes epidemics and pandemics in the human population. Oseltamivir is a neuraminidase inhibitor-a new class of antiviral therapy for influenza. Although its efficacy and safety have been established, there is uncertainty regarding whether influenza-like illness (ILI) in children is best managed by oseltamivir at the onset of illness, and its cost-effectiveness in children has not been studied in China.ObjectiveTo evaluate the cost-effectiveness of post rapid influenza diagnostic test (RIDT) treatment with oseltamivir and empiric treatment with oseltamivir comparing with no antiviral therapy against influenza for children with ILI.MethodsWe developed a decision-analytic model based on previously published evidence to simulate and evaluate 1-year potential clinical and economic outcomes associated with three managing strategies for children presenting with symptoms of influenza. Model inputs were derived from literature and expert opinion of clinical practice and research in China. Outcome measures included costs and quality-adjusted life year (QALY). All the interventions were compared with incremental cost-effectiveness ratios (ICER).ResultsIn base case analysis, empiric treatment with oseltamivir consistently produced the greatest gains in QALY. When compared with no antiviral therapy, the empiric treatment with oseltamivir strategy is very cost effective with an ICER of RMB 4,438. When compared with the post RIDT treatment with oseltamivir, the empiric treatment with oseltamivir strategy is dominant. Probabilistic sensitivity analysis projected that there is a 100% probability that empiric oseltamivir treatment would be considered as a very cost-effective strategy compared to the no antiviral therapy, according to the WHO recommendations for cost-effectiveness thresholds. The same was concluded with 99% probability for empiric oseltamivir treatment being a very cost-effective strategy compared to the post RIDT treatment with oseltamivir.ConclusionIn the Chinese setting of current health system, our modelling based simulation analysis suggests that empiric treatment with oseltamivir to be a cost-saving and very cost-effective strategy in managing children with ILI.

Project description:Human bocavirus-1 (HBoV-1) has been associated with respiratory infections in both children and adults, often presenting symptoms similar to those of influenza. Understanding the prevalence and molecular characteristics of HBoV-1 in individuals with influenza-like illness (ILI) is essential for enhancing the diagnosis and treatment of respiratory infections in Kunming, Southwest China. Between December 2017 and December 2023, demographic and clinical data, along with respiratory tract specimens from individuals aged 0 to 97 years with ILI, were collected at three sentinel hospitals in Kunming. Each specimen was tested for 18 respiratory viruses, and the positive rates of HBoV-1 across different age groups were analyzed. Amplification of the near-complete HBoV genome was achieved through three overlapping fragments, followed by next-generation sequencing (NGS) and phylogenetic analysis. A total of 20,181 respiratory samples were collected from patients aged 1 month to 97 years presenting with ILI symptoms between December 2017 and December 2023, with HBoV detected in 0.8% of the samples. The prevalence was 1.0% (165/16,406) in children and 0.1% (3/3,775) in adults, with a significantly higher detection rate in pediatric patients (<18 years old) compared to adults (≥18 years old) (P < 0.001). Among the 168 HBoV-positive participants, 165 (98.2%) were children under 18 years, while 3 (1.8%) were adults. Genome-wide phylogenetic analyses indicated that HBoV-1 was the predominant genotype, showing that the HBoV-1 strains circulating in Kunming are closely related to strains from other regions of China and globally. Our findings confirm the prevalence of HBoV-1 in individuals with ILI in Kunming and provide valuable insights into the molecular characteristics of HBoV-1 in this region. Further studies are necessary to explore the clinical implications of HBoV-1 infection and its role in respiratory illnesses.IMPORTANCEViral respiratory infections are a leading cause of morbidity- and mortality-associated influenza-like illness (ILI) cases. It is estimated that there are several billion cases of ILI globally each year. Monitoring data from China in 2023 indicate that there are approximately 17 million cases of ILI nationwide. In the United States, the annual incidence of ILI ranges from 9 to 49 million cases. Human bocavirus-1 (HBoV-1) has been identified as a causative agent of ILI. The global prevalence of HBoV-1 respiratory infections varies from 1% to 56.8%, with the majority of studies focusing on pediatric populations; however, research including a broader age range is limited. Currently, the prevalence of HBoV-1 in the Kunming area is not well characterized, and its molecular features remain inadequately described. This study aims to analyze the prevalence of HBoV-1 among ILI cases in Kunming, encompassing both pediatric and adult patients. We present 107 complete genomic sequences of HBoV-1 strains obtained from three ILI sentinel hospitals in the region. Furthermore, we conducted phylogenetic analysis, homology comparisons, and assessments of nucleotide and amino acid substitution site variations. These findings provide important insights for further investigations into HBoV-1 and its epidemiological significance.

Dataset Information

Circulation of human metapneumovirus among children with influenza-like illness in Wuhan, China.

Publications

Circulation of human metapneumovirus among children with influenza-like illness in Wuhan, China.

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