Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures.

ABSTRACT:

Objective

In the randomised scleroderma: Cyclophosphamide Or Transplantation (SCOT trial) (NCT00114530), myeloablation, followed by haematopoietic stem cell transplantation (HSCT), led to improved clinical outcomes compared with monthly cyclophosphamide (CYC) treatment in systemic sclerosis (SSc). Herein, the study aimed to determine global molecular changes at the whole blood transcript and serum protein levels ensuing from HSCT in comparison to intravenous monthly CYC in 62 participants enrolled in the SCOT study.

Methods

Global transcript studies were performed at pretreatment baseline, 8 months and 26 months postrandomisation using Illumina HT-12 arrays. Levels of 102 proteins were measured in the concomitantly collected serum samples.

Results

At the baseline visi

SUBMITTER: Assassi S 

PROVIDER: S-EPMC7167108 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature