Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis.

ABSTRACT: Patients with rheumatoid arthritis (RA) may display atypical CD21^-/lo B cells in their blood, but the implication of this observation remains unclear. We report here that the group of patients with RA and elevated frequencies of CD21^-/lo B cells shows decreased ataxia telangiectasia-mutated (ATM) expression and activation in B cells compared with other patients with RA and healthy donor controls. In agreement with ATM involvement in the regulation of V(D)J recombination, patients with RA who show defective ATM function displayed a skewed B cell receptor (BCR) Igκ repertoire, which resembled that of patients with ataxia telangiectasia (AT). This repertoire was characterized by increased Jκ1 and decreased upstream Vκ gene segment usage, suggesting improper secondary rec

SUBMITTER: Mensah KA 

PROVIDER: S-EPMC7167286 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature