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Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics.

ABSTRACT: Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.

SUBMITTER: Vannice KS

PROVIDER: S-EPMC7167332 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics.

Vannice Kirsten S KS Ricaldi Jessica J Nanduri Srinivas S Fang Ferric C FC Lynch John B JB Bryson-Cahn Chloe C Wright Theodore T Duchin Jeff J Kay Meagan M Chochua Sopio S Van Beneden Chris A CA Beall Bernard B

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20200601 1

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance. ...[more]

PMID: 31630171

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