Network and cellular mechanisms underlying heterogeneous excitatory/inhibitory balanced states.

ABSTRACT: Recent work has explored spatiotemporal relationships between excitatory (E) and inhibitory (I) signaling within neural networks, and the effect of these relationships on network activity patterns. Data from these studies have indicated that excitation and inhibition are maintained at a similar level across long time periods and that excitatory and inhibitory currents may be tightly synchronized. Disruption of this balance-leading to an aberrant E/I ratio-is implicated in various brain pathologies. However, a thorough characterization of the relationship between E and I currents in experimental settings is largely impossible, due to their tight regulation at multiple cellular and network levels. Here, we use biophysical neural network models to investigate the emergence and properties of b

SUBMITTER: Wu J 

PROVIDER: S-EPMC7167346 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature