Two Lineages of <i>KLRA</i> with Contrasting Transcription Patterns Have Been Conserved at a Single Locus during Ruminant Speciation.

ABSTRACT: Cattle possess the most diverse repertoire of NK cell receptor genes among all mammals studied to date. Killer cell receptor genes encoded within the NK complex and killer cell Ig-like receptor genes encoded within the leukocyte receptor complex have both been expanded and diversified. Our previous studies identified two divergent and polymorphic KLRA alleles within the NK complex in the Holstein-Friesian breed of dairy cattle. By examining a much larger cohort and other ruminant species, we demonstrate the emergence and fixation of two KLRA allele lineages (KLRA*01 and -*02) at a single locus during ruminant speciation. Subsequent recombination events between these allele lineages have increased the frequency of KLRA*02 extracellular domains. KLRA*01<

SUBMITTER: Gibson MS 

PROVIDER: S-EPMC7167460 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature