Prednisolone for the first rhinovirus-induced wheezing and 4-year asthma risk: A randomized trial.

ABSTRACT:

Background

Previous findings show that corticosteroid treatment during the first acute wheezing episode may reduce recurrent wheezing in children with high rhinovirus genome load at 12-month follow-up. Longer-term effects have not been investigated prospectively.

Methods

After PCR confirmation of rhinovirus from nasopharyngeal aspirate, 79 children with the first acute wheezing episode were randomized to receive orally prednisolone or placebo for 3 days. The initiation of asthma control medication before the age of 5 years was confirmed from medical record and/or from parental interview. The outcome was the time to initiation of regular asthma control medication. Interaction analysis examined rhinovirus genome load.

Results

Fifty-nine (75%) children completed the foll

SUBMITTER: Koistinen A 

PROVIDER: S-EPMC7168117 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature