Metabolic Changes of Mycobacterium tuberculosis during the Anti-Tuberculosis Therapy.

ABSTRACT: Tuberculosis, caused by Mycobacterium tuberculosis complex bacteria, remains one of the most pressing health problems. Despite the general trend towards reduction of the disease incidence rate, the situation remains extremely tense due to the distribution of the resistant forms. Most often, these strains emerge through the intra-host microevolution of the pathogen during treatment failure. In the present study, the focus was on three serial clinical isolates of Mycobacterium tuberculosis Beijing B0/W148 cluster from one patient with pulmonary tuberculosis, to evaluate their changes in metabolism during anti-tuberculosis therapy. Using whole genome sequencing (WGS), 9 polymorphisms were determined, which occurred in a stepwise or transient manner during treatment and were link

SUBMITTER: Bespyatykh J 

PROVIDER: S-EPMC7168336 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature