Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt.

ABSTRACT:

Background

Suicide is major public health concern. It is imperative to find robust biomarkers so that at-risk individuals can be identified in a timely and reliable manner. Previous work suggests mechanistic links between increased cytokines and risk for suicide, but questions remain regarding the etiology of this association, as well as the roles of sex and BMI.

Methods

Analyses were conducted using a randomly-ascertained extended-pedigree sample of 1882 Mexican-American individuals (60% female, mean age = 42.04, range = 18-97). Genetic correlations were calculated using a variance components approach between the cytokines TNF-α, IL-6 and IL-8, and Lifetime Suicide Attempt and Current Suicidal Ideation. The potentially confounding effects of sex and BMI were considered.

SUBMITTER: Knowles EEM 

PROVIDER: S-EPMC7168352 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature