Insights into virus capsid assembly from non-covalent mass spectrometry.

ABSTRACT: The assembly of viral proteins into a range of macromolecular complexes of strictly defined architecture is one of Nature's wonders. Unraveling the details of these complex structures and the associated self-assembly pathways that lead to their efficient and precise construction will play an important role in the development of anti-viral therapeutics. It will also be important in bio-nanotechnology where there is a plethora of applications for such well-defined macromolecular complexes, including cell-specific drug delivery and as substrates for the formation of novel materials with unique electrical and magnetic properties. Mass spectrometry has the ability not only to measure masses accurately but also to provide vital details regarding the composition and stoichiometry of intact, non-c

SUBMITTER: Morton VL 

PROVIDER: S-EPMC7168407 | biostudies-literature | 2008 Nov-Dec

REPOSITORIES: biostudies-literature