Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection.

ABSTRACT: The replication of virus in secondary lymphoid organs is crucial for the activation of antigen-presenting cells. Balanced viral replication ensures the sufficient availability of antigens and production of cytokines, and both of which are needed for virus-specific immune activation and viral elimination. Host factors that regulate coordinated viral replication are not fully understood. In the study reported here, we identified Map3k14 as an important regulator of enforced viral replication in the spleen while performing genome-wide association studies of various inbred mouse lines in a model of lymphocytic choriomeningitis virus (LCMV) infection. When alymphoplasia mice (aly/aly, Map3k14aly/aly, or Nikaly/aly), which carry a mutation in Map3k14, were infected with LCMV or vesicular stomati

SUBMITTER: Hamdan TA 

PROVIDER: S-EPMC7168624 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature