Human Microglia Respond to Malaria-Induced Extracellular Vesicles.

ABSTRACT: Microglia are the chief immune cells of the brain and have been reported to be activated in severe malaria. Their activation may drive towards neuroinflammation in cerebral malaria. Malaria-infected red blood cell derived-extracellular vesicles (MiREVs) are produced during the blood stage of malaria infection. They mediate intercellular communication and immune regulation, among other functions. During cerebral malaria, the breakdown of the blood-brain barrier can promote the migration of substances such as MiREVs from the periphery into the brain, targeting cells such as microglia. Microglia and extracellular vesicle interactions in different pathological conditions have been reported to induce neuroinflammation. Unlike in astrocytes, microglia-extracellular vesicle interaction has not ye

SUBMITTER: Mbagwu SI 

PROVIDER: S-EPMC7168629 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature