A Comprehensive Analysis of Nuclear-Encoded Mitochondrial Genes in Schizophrenia.

ABSTRACT:

Background

The genetic risk factors of schizophrenia (SCZ), a severe psychiatric disorder, are not yet fully understood. Multiple lines of evidence suggest that mitochondrial dysfunction may play a role in SCZ, but comprehensive association studies are lacking. We hypothesized that variants in nuclear-encoded mitochondrial genes influence susceptibility to SCZ.

Methods

We conducted gene-based and gene-set analyses using summary association results from the Psychiatric Genomics Consortium Schizophrenia Phase 2 (PGC-SCZ2) genome-wide association study comprising 35,476 cases and 46,839 control subjects. We applied the MAGMA method to three sets of nuclear-encoded mitochondrial genes: oxidative phosphorylation genes, other nuclear-encoded mitochondrial genes, and genes involved

SUBMITTER: Goncalves VF 

PROVIDER: S-EPMC7168759 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature