Spinal cord NLRP1 inflammasome contributes to dry skin induced chronic itch in mice.

ABSTRACT:

Background

Dry skin itch is one of the most common skin diseases and elderly people are believed to be particularly prone to it. The inflammasome has been suggested to play an important role in chronic inflammatory disorders including inflammatory skin diseases such as psoriasis. However, little is known about the role of NLRP1 inflammasome in dry skin-induced chronic itch.

Methods

Dry skin-induced chronic itch model was established by acetone-ether-water (AEW) treatment. Spontaneous scratching behavior was recorded by video monitoring. The expression of nucleotide oligomerization domain (NOD)-like receptor protein 1 (NLRP1) inflammasome complexes, transient receptor potential vanilloid type 1 (TRPV1), and the level of inflammatory cytokines were determined by western blot,

SUBMITTER: Fan JJ 

PROVIDER: S-EPMC7168883 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature