Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds.

ABSTRACT: Pelagic seabirds are amongst the most threatened of all avian groups. They face a range of immunological challenges which seem destined to increase due to environmental changes in their breeding and foraging habitats, affecting prey resources and exposure to pollution and pathogens. Therefore, the identification of biomarkers for the assessment of their health status is of considerable importance. Peptidylarginine deiminases (PADs) post-translationally convert arginine into citrulline in target proteins in an irreversible manner. PAD-mediated deimination can cause structural and functional changes in target proteins, allowing for protein moonlighting in physiological and pathophysiological processes. PADs furthermore contribute to the release of extracellular vesicles (EVs), which play imp

SUBMITTER: Phillips RA 

PROVIDER: S-EPMC7168935 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature