Partially latent class models for case-control studies of childhood pneumonia aetiology.

ABSTRACT: In population studies on the aetiology of disease, one goal is the estimation of the fraction of cases that are attributable to each of several causes. For example, pneumonia is a clinical diagnosis of lung infection that may be caused by viral, bacterial, fungal or other pathogens. The study of pneumonia aetiology is challenging because directly sampling from the lung to identify the aetiologic pathogen is not standard clinical practice in most settings. Instead, measurements from multiple peripheral specimens are made. The paper introduces the statistical methodology designed for estimating the population aetiology distribution and the individual aetiology probabilities in the Pneumonia Etiology Research for Child Health study of 9500 children for seven sites around the wor

SUBMITTER: Wu Z 

PROVIDER: S-EPMC7169268 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature