Binding Constants of Substituted Benzoic Acids with Bovine Serum Albumin.

ABSTRACT: Experimental data on the affinity of various substances to albumin are essential for the development of empirical models to predict plasma binding of drug candidates. Binding of 24 substituted benzoic acid anions to bovine serum albumin was studied using spectrofluorimetric titration. The equilibrium constants of binding at 298 K were determined according to 1:1 complex formation model. The relationships between the ligand structure and albumin affinity are analyzed. The binding constant values for m- and p-monosubstituted acids show a good correlation with the Hammett constants of substituents. Two- and three-parameter quantitative structure-activity relationship (QSAR) models with theoretical molecular descriptors are able to satisfactorily describe the obtained values for the whole set

SUBMITTER: Khaibrakhmanova D 

PROVIDER: S-EPMC7169394 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature