Wounds Inhibit Tumor Growth In Vivo.

ABSTRACT:

Objective

The aim of this study was to determine the interaction of full thickness excisional wounds and tumors in vivo.

Summary of background data

Tumors have been described as wounds that do not heal due to similarities in stromal composition. On the basis of observations of slowed tumor growth after ulceration, we hypothesized that full thickness excisional wounds would inhibit tumor progression in vivo.

Methods

To determine the interaction of tumors and wounds, we developed a tumor xenograft/allograft (human head and neck squamous cell carcinoma SAS/mouse breast carcinoma 4T1) wound mouse model. We examined tumor growth with varying temporospatial placement of tumors and wounds or ischemic flap. In addition, we developed a tumor/wound parabiosis model to understan

SUBMITTER: Hu MS 

PROVIDER: S-EPMC7169436 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature