A 90 day oral toxicity study of blueberry polyphenols in ovariectomized sprague-dawley rats.

ABSTRACT: Regular consumption of polyphenol-rich fruits and vegetables is associated with beneficial health outcomes. To increase polyphenol intakes, consumers are increasingly using herbal and botanical dietary supplements containing concentrated polyphenol extracts. However, the safety of this consumption modality has not been vetted. To address this, ovariectomized Sprague-Dawley (OVX-SD) rats were orally gavaged with purified blueberry polyphenols at 0-1000 mg total polyphenols/kg bw/d for 90d. No differences in behavior, body weight, or food consumption were observed. No tumors or macroscopic changes were observed, and histopathological analyses showed no differences among groups. Although several statistically significant differences between treatment and control groups were observed in urine

SUBMITTER: Cladis DP 

PROVIDER: S-EPMC7169469 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature