Effective inactivation of a wide range of viruses by pasteurization.

ABSTRACT:

Background

Careful selection and testing of plasma reduces the risk of blood-borne viruses in the starting material for plasma-derived products. Furthermore, effective measures such as pasteurization at 60°C for 10 hours have been implemented in the manufacturing process of therapeutic plasma proteins such as human albumin, coagulation factors, immunoglobulins, and enzyme inhibitors to inactivate blood-borne viruses of concern. A comprehensive compilation of the virus reduction capacity of pasteurization is presented including the effect of stabilizers used to protect the therapeutic protein from modifications during heat treatment.

Study design and methods

The virus inactivation kinetics of pasteurization for a broad range of viruses were evaluated in the relevant intermedi

SUBMITTER: Groner A 

PROVIDER: S-EPMC7169671 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature