Self-awareness of problematic drug use: Preliminary validation of a new fMRI task to assess underlying neurocircuitry.

ABSTRACT:

Background

Multiple psychopathologies feature impaired clinical insight. Emerging evidence suggests that insight problems may similarly characterize addiction, perhaps due to aberrant functioning of self-referential brain circuitry, including the rostral anterior cingulate and ventromedial prefrontal cortices (rACC/vmPFC). We developed a new fMRI task to probe whether rACC/vmPFC abnormalities in cocaine use disorder (CUD) constitute neural correlates of readiness to change, one facet of insight.

Methods

Eighteen individuals with current CUD and 15 healthy controls responded about their own need to change their drug use and eating behavior (control condition) and the need for a named acquaintance to do the same (two additional control conditions). Measures of simulated drug-c

SUBMITTER: Moeller SJ 

PROVIDER: S-EPMC7170015 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature