Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway.

ABSTRACT: Osteosarcoma is the most common primary malignant tumor of the bone and the long‑term survival of patients with this disease has remained unsatisfactory over the past several decades. Andrographolide, a traditional drug used in Chinese medicine, has been found to exert a significant antitumor effect against several types of cancer. However, relatively little is known about the effect of andrographolide on osteosarcoma and the underlying mechanisms. In the present study, it was shown that andrographolide inhibited osteosarcoma cell proliferation by arresting the cell cycle at the G2/M phase and increasing caspase‑mediated apoptosis. Furthermore, treatment with andrographolide induced JNK activation and increased production of reactive oxygen species (ROS). The andrographolide‑triggered apop

SUBMITTER: Wang S 

PROVIDER: S-EPMC7170044 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature