The impact of phenotype, ethnicity and genotype on progression of type 2 diabetes mellitus.

ABSTRACT:

Aim

To conduct a comprehensive review of studies of glycaemic deterioration in type 2 diabetes and identify the major factors influencing progression.

Methods

We conducted a systematic literature search with terms linked to type 2 diabetes progression. All the included studies were summarized based upon the factors associated with diabetes progression and how the diabetes progression was defined.

Results

Our search yielded 2785 articles; based on title, abstract and full-text review, we included 61 studies in the review. We identified seven criteria for diabetes progression: 'Initiation of insulin', 'Initiation of oral antidiabetic drug', 'treatment intensification', 'antidiabetic therapy failure', 'glycaemic deterioration', 'decline in beta-cell function' and 'change

SUBMITTER: Thakarakkattil Narayanan Nair A 

PROVIDER: S-EPMC7170456 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature