Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer.

ABSTRACT:

Introduction

Oncogenic activation of ERG resulting from TMPRSS2-ERG gene fusion is a key molecular genetic alteration in prostate cancer (CaP). The frequency of ERG fusion is variable by race; however, there are limited data available on germline polymorphisms associating with ERG fusion status. The goal of this study is to identify the inherited risk variants associating with ERG status of CaP.

Materials and methods

SNP genotyping was performed on the Illumina platform using Infinium Oncoarray SNP chip on blood derived genomic DNA samples from 400 patients treated by radical prostatectomy at a single military institution. ERG status was determined in whole mounted prostate specimens by immuno-histochemistry (IHC) for ERG protein expression. Data analysis approaches i

SUBMITTER: Kohaar I 

PROVIDER: S-EPMC7170497 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature