The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice.

ABSTRACT: Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. However, its functional mechanisms remain unknown. Here we observed widespread MEIS2 expression in the developing palate in mice. Wnt1^Cre -mediated Meis2 inactivation in cranial neural crest cells led to a secondary palate cleft. Importantly, about half of the Wnt1^Cre ;Meis2^f/f mice exhibited a submucous cleft, providing a model for studying palatal bone formation and patterning. Consistent with complete absence of palatal bones, the results from integrative analyses of MEIS2

SUBMITTER: Wang L 

PROVIDER: S-EPMC7170518 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature