Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol.

ABSTRACT:

Introduction

Timing of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups. Previous and current trials compare various policies, including time-based or physiology-based deferred cord clamping, and cord milking. Individual participant data (IPD) enable exploration of different strategies within subgroups. Network meta-analysis (NMA) enables comparison and ranking of all available interventions using a combination of direct and indirect comparisons.

Objectives

(1) To evaluate the effectiveness of cord management strategies for preterm infants on neonatal mortality and morbidity overall and for different participant characteristics using IPD meta-analysis. (2) To evalu

SUBMITTER: Seidler AL 

PROVIDER: S-EPMC7170588 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature