Maternal multivitamin intake and orofacial clefts in offspring: Japan Environment and Children's Study (JECS) cohort study.

ABSTRACT:

Objectives

Orofacial clefts are common birth defects with a lack of strong evidence regarding their association with maternal nutrition. We aimed to determine whether a relationship exists between maternal nutrient or multivitamin intake and orofacial clefts.

Design

This is a prospective, population-based nationwide cohort study.

Setting

The study was conducted in 15 regional centres, consisting of local administrative units and study areas.

Participants

A total of 98 787 eligible mother-child pairs of the Japan Environment and Children's Study were included.

Intervention

Exposures were maternal nutrition and the use of supplemental multivitamins in mothers.

Primary and secondary outcome measures

Outcomes were the occurrence of any orofacial cleft

SUBMITTER: Yoshida S 

PROVIDER: S-EPMC7170615 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature