Ontology highlight
ABSTRACT:
SUBMITTER: Bruininks BM
PROVIDER: S-EPMC7170654 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bruininks Bart Mh BM Souza Paulo Ct PC Ingolfsson Helgi H Marrink Siewert J SJ
eLife 20200416
The use of non-viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of preparing the vectors. A promising approach to non-viral vectors makes use of DNA/cationic liposome complexes (lipoplexes) to deliver the genetic material. Here we use coarse-grained molecular dynamics simulations to investigate the molecular mechanism underlying efficient DNA transfer from lipoplexes. Our computational fusion experiments of lipoplexes with endosomal membrane mode ...[more]