Is Switching from Oral Antidiabetic Therapy to Insulin Associated with an Increased Fracture Risk?

ABSTRACT:

Background

Observational studies showed that exposure to exogenous insulin increases fracture risk. However, it remains unclear whether the observed association is a function of the severity of underlying type 2 diabetes mellitus, complications, therapies, comorbidities, or all these factors combined. That being so, and because of the relative infrequency of these events, it is important to study this further in a large-database setting. QUESTION/PURPOSES: (1) Is switching from oral antidiabetic agents to insulin associated with an increased fracture risk? (2) How soon after switching does the increased risk appear, and for how long does this increased risk persist?

Methods

Data from healthcare utilization databases of the Italian region of Lombardy were used. These healthca

SUBMITTER: Corrao G 

PROVIDER: S-EPMC7170699 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature