Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour.

ABSTRACT:

Background

Over-the-counter analgesics during pregnancy or infancy may be related to neurobehavioural problems in children, but little is known about effects of different analgesic types, dosage, and timing.

Objectives

Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children.

Methods

We included 1225 mother-child pairs from Project Viva, a pre-birth cohort study. We assessed prenatal acetaminophen and ibuprofen use in early and mid-pregnancy and infant use in the first year of life using questionnaires. Parents and classroom teachers assessed child behaviours in mid-childhood (median 8 years), using the Behavior Rating Inventory of Executive Function (BRIEF) and the Strengths and Di

SUBMITTER: Rifas-Shiman SL 

PROVIDER: S-EPMC7170759 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature