PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis.

ABSTRACT: Prominin 1 (PROM1) is considered a biomarker for cancer stem cells, although its biological role is unclear. Prominin 2 (PROM2) has also been associated with certain cancers. However, the prognostic value of PROM1 and PROM2 in cancer is controversial. Here, we performed a systematic data analysis to examine whether prominins can function as prognostic markers in human cancers. The expression of prominins was assessed and their prognostic value in human cancers was determined using univariate and multivariate survival analyses, via various online platforms. We selected a group of prominent functional protein partners of prominins by protein-protein interaction analysis. Subsequently, we investigated the relationship between mutations and copy number alterations in prominin genes and various

SUBMITTER: Saha SK 

PROVIDER: S-EPMC7170805 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature