WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications.

ABSTRACT: Obesity and its numerous adverse health consequences have taken on global, pandemic proportions. White adipose tissue (WAT) - a key contributor in many metabolic diseases - contributes about one fourth of a healthy human's body mass. Despite its significance, many WAT-related pathophysiogical mechanisms in humans are still not understood, largely due to the reliance on non-human animal models. In recent years, Organ-on-a-chip (OoC) platforms have developed into promising alternatives for animal models; these systems integrate engineered human tissues into physiological microenvironment supplied by a vasculature-like microfluidic perfusion. Here, we report the development of a novel OoC that integrates functional mature human white adipocytes. The WAT-on-a-chip is a multilayer device that f

SUBMITTER: Rogal J 

PROVIDER: S-EPMC7170869 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature