Ontology highlight
ABSTRACT:
SUBMITTER: Kim CY
PROVIDER: S-EPMC7170919 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kim Colin Y CY Mitchell Andrew J AJ Glinkerman Christopher M CM Li Fu-Shuang FS Pluskal Tomáš T Weng Jing-Ke JK
Nature communications 20200420 1
Plant halogenated natural products are rare and harbor various interesting bioactivities, yet the biochemical basis for the involved halogenation chemistry is unknown. While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been found to catalyze regioselective halogenation of unactivated C-H bonds in bacteria, they remain uncharacterized in the plant kingdom. Here, we report the discovery of dechloroacutumine halogenase (DAH) from Menispermaceae plants known to produce ...[more]