Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation.

ABSTRACT:

Objectives

Epidemiological studies indicate that first- and second-hand cigarette smoke (CS) exposure are important risk factors for the development of type 2 diabetes (T2D). Additionally, elevated diabetes risk has been reported to occur within a short period of time after smoking cessation, and health risks associated with smoking are increased when combined with obesity. At present, the mechanisms underlying these associations remain incompletely understood. The objective of this study was to test the impact of CS exposure on pancreatic β-cell function using rodent and in vitro models.

Methods

Beginning at 8 weeks of age, C57BL/6 J mice were concurrently fed a high-fat diet (HFD) and exposed to CS for 11 weeks, followed by an additional 11 weeks of smoking cessation with

SUBMITTER: Tong X 

PROVIDER: S-EPMC7170997 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature