α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease.

ABSTRACT: A diagnosis of motor Parkinson's disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal relation between α-synuclein (α-syn) T cell reactivity and PD. A longitudinal case study revealed that elevated α-syn-specific T cell responses were detected prior to the diagnosis of motor PD, and declined after. The relationship between T cell reactivity and early PD in two independent cohorts showed that α-syn-specific T cell responses were highest shortly after diagnosis of motor PD and then decreased. Additional analysis revealed significant association of α-syn-specific T cell responses with age and lower levodopa equivalent dose. These results confirm the presence of α-syn-reactive T cells in PD and show that they are most abundant

SUBMITTER: Lindestam Arlehamn CS 

PROVIDER: S-EPMC7171193 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature