Staphylococcus aureus Fibronectin Binding Protein A Mediates Biofilm Development and Infection.

ABSTRACT: Implanted medical device-associated infections pose significant health risks, as they are often the result of bacterial biofilm formation. Staphylococcus aureus is a leading cause of biofilm-associated infections which persist due to mechanisms of device surface adhesion, biofilm accumulation, and reprogramming of host innate immune responses. We found that the S. aureus fibronectin binding protein A (FnBPA) is required for normal biofilm development in mammalian serum and that the SaeRS two-component system is required for functional FnBPA activity in serum. Furthermore, serum-developed biofilms deficient in FnBPA were more susceptible to macrophage invasion, and in a model of biofilm-associated implant infection, we found that FnBPA is crucial for the establishment of infection. Together

SUBMITTER: Gries CM 

PROVIDER: S-EPMC7171244 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature