Withdrawal Symptoms From E-Cigarette Abstinence Among Adult Never-Smokers: A Pilot Experimental Study.

ABSTRACT:

Introduction

Use of e-cigarettes among never-smokers has substantially increased; yet there are few descriptions of the consequences of such use. We assessed whether adult never-smokers can have withdrawal from cessation of e-cigarettes.

Methods

In an un-blinded pre-post clinical trial, 30 never-smoker daily e-cigarette users used their own nicotine-containing e-cigarette for 7 days followed by 6 days of biologically confirmed abstinence. Participants monitored symptoms of nicotine withdrawal nightly via an Interactive Voice Response system. They attended three lab visits/week to provide expired carbon monoxide and urine samples to determine compliance.

Findings

Abstinence increased all the DSM5 symptoms of tobacco withdrawal and this occurred in the majority of parti

SUBMITTER: Hughes JR 

PROVIDER: S-EPMC7171287 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature