LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.

ABSTRACT:

Background

Leucine-rich repeat-coupled receptor 6 (LGR6) is a marker of the skin, nails, and other types of adult tissue stem cells and has been widely found to be related to the development and progression of a variety of cancer types. The clinical significance and biological function of LGR6 in esophageal squamous cell carcinoma (ESCC) have not been determined.

Methods

The expression of LGR6 at the transcriptional level was analyzed by searching the TCGA and UCSC data sets. Immunohistochemistry, WB, and q-PCR were used to detect the expression of LGR6 in ESCC and adjacent normal tissues. LGR6 PPI networks and KEGG pathways were used to analyze the potential biological functions of LGR6.

Results

The expression of LGR6 in ESCC tissues was significantly higher than tha

SUBMITTER: Chai T 

PROVIDER: S-EPMC7171331 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature