Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC7171420 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liu Zhe Z Cao Kun K Liao Zebin Z Chen Yuanyuan Y Lei Xiao X Wei Qun Q Liu Cong C Sun Xuejun X Yang Yanyong Y Cai Jianming J Gao Fu F
Journal of cellular and molecular medicine 20200305 7
Radiation protection on male testis is an important task for ionizing radiation-related workers or people who receive radiotherapy for tumours near the testicle. In recent years, Toll-like receptors (TLRs), especially TLR4, have been widely studied as a radiation protection target. In this study, we detected that a low-toxicity TLR4 agonist monophosphoryl lipid A (MPLA) produced obvious radiation protection effects on mice testis. We found that MPLA effectively alleviated testis structure damage ...[more]